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Alzheimer's disease and transition metals

 

We recommend "Trace metal concentrations in hair and nails from Alzheimer's disease patients: Relations with clinical severity."

It says that transition metals (Zn, Fe, Cu, Mn, Pb, Cd) may be important in the development of Alzheimer's disease.

A study was conducted to determine the relationship between these metals and pathogenesis and / or progression of Alzheimer's disease. The study involved 62 subjects, at various stages of clinical disease - 21 in mild, 20 in moderate and 21 in severe. The control group consisted of 60 healthy people. The research material was hair and nails analyzed by inductively coupled plasma-mass spectrometry.

Hair analysis showed large differences between patients and control group in the following elements: Na, Al, Pb, Co (p <0.001), Fe, Mn (p = 0.001), Hg, Cu, Cd, K.

Then nail analysis was analyzed, which confirmed differences in Mn, Fe, Cu, Cd, Hg (p <0.001), Zn (p <0.01).

In the case of Mg and Ca, there were practically no significant changes. The amount of sodium (Na) in the samples varied depending on the stage of Alzheimer's disease (p <0.01).

In middle-stage patients, changes were observed:  Mn, Fe, Cu, Co (p <0.001), Hg, Zn (p <0.01) in the nails and Pb, Al (p <0.001), Na, K in hair.

The study results show that transition metals are important in Alzheimer's disease. The study revealed the evolving level of Na in nails in various clinical stages. This means that alkaline metals may also affect the progression of Alzheimer's disease.

Source: "Trace metal concentrations in hair and nails from Alzheimer's disease patients: Relations with clinical severity."; Emel Koseoglu, MDa, Rahmi Koseoglu, PhDb, Murat Kendirci, MDc, Recep Saraymen, PhDd, , Burak Saraymen, MDe; J Trace Elem Med Biol. 2017 Jan.